Murkrow first debuted in Pester Control!, where he stole food from the group, using Haze to get away. He later encountered the group again while they were having dinner and stole their food once more. The group then gave chase and managed to corner Murkrow in a clearing. There, they learnt that Murkrow was giving the food to an injured Starly in order to build its strength.
After Lewis healed Starly with a Potion, Starly thanked both Lewis and Murkrow and flew away. Lewis praises Murkrow, who reluctantly thanks Lewis for the help. Lewis then challenges Murkrow to a battle, who accepts. Murkrow made good use of Haze to hide itself from Aipom, who took several powerful hits from Wing Attack. Eventually, Aipom was able to strike Murkrow with Focus Punch, sending it flying into a tree. Lewis used the opportunity to throw a Poké Ball and catch Murkrow.
Murkrow was used to help train a wild Piplup in Shock to the System!, providing some target practise while she attempted to learn Ice Beam.
In Mine Away Home!, Murkrow was sent out as Lewis' second Pokémon in his Gym battle against Roark. He battled against Roark's Onix and was able to land a few early hits with Wing Attack using Haze as a cover. However, Onix was quickly able to blow away the smoke and land a hit on Murkrow with Iron Tail. Using this to their advantage, Lewis commanded Murkrow to use Assurance, dealing more damage to Onix due to Murkrow having been hit immediately prior. After Onix used Harden to boost its Defence, Murkrow had a harder time dealing damage and was eventually defeated by Stone Edge.
Murkrow is a relatively serious Pokémon, showing little emotion in the presence of others. He is shown to have a softer side, as shown by his desire to help an injured Starly, despite not knowing it. Murkrow is also shown to be quite prideful, as seen in his reluctance when thanking Lewis for helping him.