Kyurem made its first appearance at the end of Ancient Rivals!, where it was captured by a group of Team Neo Plasma grunts led by Ghetsis and Colress. Kyurem was taken aboard the Plasma Frigate, where it was connected to Colress' Kyurem Cannon.
In Opelucid On Ice!, Team Neo Plasma forced Kyurem to use its powers to freeze Opelucid City as a "field test" of the Kyurem Cannon.
In A Liepard Once Lost!, Ghetsis uses an upgraded Kyurem Cannon to freeze the majority of Unova. The amount of energy required for it to perform such a feat caused Kyurem to rampage, escaping the cell it was imprisoned in and destroying part of the Plasma Frigate, forcing Ghetsis to make an emergency landing in Giant Chasm. Kyurem then retreated into Giant Chasm to recover, although Ghetsis gave chase, pursued by Lewis.
In the following episode, Ghetsis managed to gain control over Kyurem using a device on his cane. After losing against Lewis once again, Ghetsis had Kyurem use Glaciate on Lewis and his Pokémon in order to freeze them solid. This attempt was foiled by N's Reshiram.
Ghetsis then used Kyurem's Absofusion ability to force Reshiram and Zekrom back into the Light and Dark Stones respectively, thus allowing Kyurem to absorb them and gain the ability to change into White Kyurem and Black Kyurem. In these forms, Kyurem proved too powerful for Lewis, but he and N managed to remind Reshiram and Zekrom of their respective bonds, allowing them to separate from Kyurem. Kyurem then battled both Reshiram and Zekrom, but was defeated by a combination of Fusion Flare and Fusion Bolt, breaking Ghetsis' control.
After Ghetsis was arrested and Team Neo Plasma disbanded, Kyurem was seen retreating further into the depths of Giant Chasm.
Not much is known about Kyurem's personality, as it spent the majority of its appearances under the control of Team Neo Plasma. While under Ghetsis' control, Kyurem was shown to be ruthless in battle and fought without much care for its opponent's wellbeing, much like Ghetsis himself. After being freed by Lewis and N, it showed gratitude to them, suggesting that it is not an inherently bad Pokémon. Its silent retreat into Giant Chasm could suggest that Kyurem prefers solidarity.